Clean Brain — AHA! Discovery on Healing Requires Energy for April 2022

February 2022 – Fluid transport into and out of the brain has more obstacles when compared to the various ways of typical cellular (non-neuro) hydration. As we discussed in a previous article, electrical potential attraction or for neuro scientists, the term is “action potential” of ion movement also occurs at the blood-brain barrier (BBB) as well as in the axons of the nerve cells. But the BBB with its closely packed endothelial cells connected with tight junctions (hydrophobic core of lipid layers) create a physical barrier against large molecules carried in by our spinal blood system such as toxins, molds, bacteria, viruses, and even pharmaceutical compounds. For the latter, researchers continue to look for drug delivery mechanisms to treat brain-related diseases without damaging the integrity of the BBB. Smaller molecules on the other hand, such as caffeine, nicotine and alcohol that can be made lipid soluble, permeate across the BBB lipid layers which explains the reactions of our brain cells.

One article states … “Almost no large molecules and 98% of all small molecules do not cross the BBB … Many molecules that cross the membrane by passive transport are subsequently transported back to the vascular system by efflux pumps”. It is also interesting to read about the constant energy needs of the brain and how the brain communicates nourishment and hydration on demand to cross the BBB; otherwise tragic nerve cell damage can immediately occur.

Fortunately, water can permeate across the BBB. Gas molecules (oxygen and hydrogen) have an even faster diffusion which explains the neuro absorption of DiTetra Gas. Infusing the eyes with DiTetra Gas is also a pathway to the brain.

How Does the Brain Clean Itself?

Cerebrospinal fluid is critical in providing nourishment and hydration to the brain cells for mitochondrial energy production which supports neuron signaling messages. However, buildup of proteins including amyloids and other toxins in the cerebrospinal fluid can cause neurological damage. How does the brain clean itself? Although there are some “shuttles” or efflux pumps to send back solutes coming across the BBB, the basically impermeable BBB also can defend in the opposite way to keep fluids inside the brain.

Brain cleansing outlets remain a scientific mystery. “It’s amazing that this is such a basic anatomical question and we don’t know how something as important as fluid around the brain is cleared out,” says Steven Proulx at the University of Bern in Switzerland. Proulx mentions that some of the fluid flows out of the nose and eyes. He continues …“Knowing where this flow happens is important for understanding immune reactions that can occur through the central nervous system and how toxic proteins like amyloids could be removed”.

All of the 2022 “Healing Requires Energy” Series can be found here.

Sharing AHA! Discoveries

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